In 2002, Dr. Adrienne Randolph founded the Pediatric Acute Lung Injury and Sepsis Investigator’s (PALISI) Network, a consortium of clinical researchers who work in pediatric intensive care units across over 80 institutions in the U.S. and Canada. Influenza infection becomes life-threatening when it causes severe injury to the lung or when the infection impairs the function of other vital organs causing overwhelming sepsis.  Led by Dr. Randolph, some sites in the PALISI Network were funded by the U.S. Centers for Disease Control and Prevention (CDC) Public Health Genomics Division to study how a person’s genes influence their response to influenza virus, including why some children and young adults get very sick when most others don’t. We called it the Pediatric Intensive Care Influenza (PICFLU) Study.


In the late spring and summer of 2009, while we were enrolling patients, the 2009 H1N1 influenza pandemic spread rapidly across the United States. We received a five-year grant to continue studying the immune response to influenza infection from the National Institute of Allergy and Infectious Diseases (NIAID). We also received funding from the National Heart Lung and Blood Institute (NHLBI) to partner with ARDSNet to collect data during the pandemic and study its effect on patients and clinical resources.


The PICFLU Network has grown and we have performed many studies which are described on our website. We thank the organizations below for funding these studies.



 The PICFLU investigators are responsible for the content of this website, and not our funders.

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