PICFLU Publications

PICFLU Immunobiology of Influenza Critical Illness in Young Hosts

• Transcriptomic profiles of multiple organ dysfunction syndrome phenotypes in pediatric critical influenza. Published in Frontiers in Immunology (2023)
• Single cell transcriptomics identifies distinct profiles in pediatric acute respiratory distress syndrome. Published in Nature Communications (2023)
• Longitudinal Analysis of Contrasts in Gene Expression Data. Published in Genes (2023)
• Host Respiratory Transcriptome Signature Associated with Poor Outcome in Children with Influenza?Staphylococcus aureus Pneumonia. Published in The Journal of Infectious Diseases (2022)
• DDX58 is Associated with Susceptibility to Severe Influenza Virus Infection in Children and Adolescents. Published in Journal of Infectious Diseases (2022)
• Life-Threatening Complications of Influenza versus COVID-19 in U.S. Children. Published in Clinical Infectious Diseases (2022)
• Surfactant protein D is a biomarker of influenza-related pediatric lung injury. Published in Pediatric Pulmonology (2021)
• RIG-I and TLR4 responses and adverse outcomes in pediatric influenza-related critical illness. Published in Journal of Allergy and Clinical Immunology (2020)
• A Modular Cytokine Analysis Method Reveals Novel Associations With Clinical Phenotypes and Identifies Sets of Co-signaling Cytokines Across Influenza Natural Infections Cohorts and Healthy Controls. Published in Frontiers in Immunology (2019)
• Evaluation of Mannose Binding Lectin Gene Variants in Pediatric Influenza Virus-Related Critical Illness. Published in Frontiers in Immunology (2019)
• Bioactive lipids serve as biomarkers of host immune response during severe influenza infection in pediatric patients. Published in the Journal of Immunology (2018)
• Vancomycin monotherapy may be insufficient to treat methicillin-resistant Staphylococcus aureus coinfection in children with influenza-related critical illness. Published in Clinical Infectious Diseases (2018)
• Cytokine profiles of severe influenza virus-related complications in children. Published in Frontiers in Immunology (2017)
• SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans. Published in Nature Medicine (2017)
• Evaluation of IFITM3 rs12252 association with severe pediatric influenza infection. Published in the Journal of Infectious Diseases (2017)
• Staphylococcus aureus ?-toxin response distinguishes respiratory virus-MRSA co-infection in children. Published in the Journal of Infectious Diseases (2016)
• Innate immune function and mortality in critically ill children with influenza: a multicenter study. Published in Critical Care Medicine (2013)
  
  

Understanding Severe Influenza in Pediatrics

• High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral disease. Published in Cell (2024)
  
  

PICFLU Vaccine Effectiveness Study

• Association of Asthma With Treatments and Outcomes in Children With Critical Influenza. Published in The Journal of Allergy and Clinical Immunology: In Practice (2023)
• Vaccine Effectiveness Against Life-Threatening Influenza Illness in US Children. Published in Clinical Infectious Diseases (2022)
• Optimizing Virus Identification in Critically Ill Children Suspected of Having an Acute Severe Viral Infection. Published in Pediatric Critical Care Medicine (2016)
• Effectiveness of influenza vaccine against life-threatening RT-PCR-confirmed influenza illness in US children, 2010-2012. Published in the Journal of Infectious Diseases (2014)
• Variability in IRBs regarding parental acceptance of passive consent. Published in Pediatrics (2014)
  
  

PICFLU Pandemic Preparedness Study

• Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States. Published in Critical Care Medicine (2012)
• Critically ill children during the 2009-2010 influenza pandemic in the United States. Published in Pediatrics (2011)
• Early observational research and registries during the 2009-2010 influenza A pandemic. Published in Critical Care Medicine (2010)
• InFACT: a global critical care research response to H1N1. Published in the Lancet (2010)
  
  

Other Collaborative Projects

• WHO public health research agenda for influenza: 2017 update. Published through the World Health Organization (2017)
• Mannose-binding lectin levels in critically ill children with severe infections. Published in Pediatric Critical Care Medicine (2017)